PartiQlar focuses on supporting longevity, cellular metabolism, and vitality through its range of offerings. These offerings feature compounds like NAD+, spermidine, and resveratrol, all of which are associated with antioxidant support and anti-aging benefits. The brand also offers curated kits and bundles for added convenience.
In this review, we evaluate the brand’s positioning, core background, range of featured offerings, associated brand advantages, and potential limitations. The review further compares the brand with similar brands operating in the longevity-focused space.
About PartiQlar
PartiQlar positions itself as a US-based longevity-focused brand built around single-ingredient formulation standards, documentation access, and a catalog structured around NAD+ and healthy aging routines.
Some featured offerings include Pure NAD+ Capsules, Pure NR, Pure Resveratrol Capsules, Pure Spermidine, Pure Berberine HCL, and Pure Magnesium Glycinate. The brand also offers the Healthy Aging Bundle, Longevity Starter Bundle, and Anti-Inflammatory Bundle as bundled stacks.
According to its official website, the brand states that all its products are manufactured in U.S.-based facilities that are FDA- and NSF-registered and operate under GMP standards. It also highlights an avoid list of additives and processed ingredients it claims to exclude, including binders, magnesium stearate, GMOs, hydrogenated oils, and artificial colors, flavors, and sweeteners.
PartiQlar Bestsellers
Pure NAD+
Pure NAD+ Capsules intend to support healthy NAD+ levels, which may support cellular energy, metabolic function, and healthy aging. The brand frames NAD+ as a foundational cellular coenzyme linked to energy production and cellular repair functions that typically decline with age.
NAD+ (nicotinamide adenine dinucleotide) is known as a coenzyme found in virtually all cells and supports redox reactions required for ATP generation, meaning it helps mitochondria convert nutrients into usable cellular energy. It is also required for the activity of enzymes involved in cellular maintenance pathways, including sirtuins (linked to metabolic regulation and stress responses) and PARPs (involved in DNA repair signaling).Pure NR
Pure NR is formulated to support NAD+ restoration and promote cellular metabolism pathways. As per its official site, one capsule provides 500mg of nicotinamide riboside chloride. The manufacturers claim to use delayed-release, enteric-coated capsules, intended to protect NR from breakdown in the stomach and promote release further along the digestive tract.
Nicotinamide riboside enters NAD+ salvage pathways, thereby supporting production of NAD+ (nicotinamide adenine dinucleotide). NAD+ works to support mitochondrial energy metabolism by helping drive redox reactions needed for ATP generation. When NAD+ levels decline, energy efficiency and repair signaling may become less consistent. Pure NR intends to minimize such risks by restoring NAD+ levels.Pure Berberine HCL
Pure Berberine HCL may help support metabolism, with a primary focus on stabilizing blood glucose levels, insulin sensitivity, and lipid balance. According to its official website, the formulation contains 600mg of 97% pure berberine hydrochloride (HCL) per capsule.
Berberine is a plant-derived alkaloid that could activate AMP-activated protein kinase (AMPK), an energy-sensing pathway that influences glucose uptake into cells, fatty acid oxidation, and fuel handling. AMPK activation can improve how cells respond to insulin signals, which may help lower fasting glucose levels and reduce post-meal blood sugar spikes.Pure Berberine HCL could also influence lipid metabolism. Berberine in the formulation may help support potential reductions in LDL cholesterol and triglycerides, which might contribute to improved cardiovascular health markers.
Pure L-Theanine
Pure L-Theanine may help improve the body’s stress resilience, support calmer mood balance, and promote mental focus without promoting a sedated feeling. The formulation is described as a non-drowsy calming option that may be taken either in the evening to unwind or earlier in the day to support calmer concentration.
L-theanine amino acid, helps in increasing alpha brain wave activity, which could promote a calm but awake mental state. It may also influence neurotransmitter activity, including GABA, serotonin, and dopamine, which may further support mood steadiness, perceived stress, and emotional reactivity.Pure Alpha GPC
Pure Alpha GPC by partiQlar is a choline-based formulation intended to support memory, focus, learning efficiency, and brain performance. As per its official website, one capsule provides 300mg of 99% pure alpha-glycerylphosphorylcholine (Alpha GPC). For use, the makers suggest taking one capsule about one hour before engaging in high-focus work or a workout, with optional dose adjustments depending on the desired intensity of support.
The manufacturer highlights that Pure Alpha GPC is enclosed in a microcrystalline cellulose capsule. Such an approach is positioned to prioritize direct Alpha GPC delivery without stacking multiple actives that might complicate tolerability or timing for focus-based use. Alpha GPC functions primarily as a choline donor, meaning it supplies choline that can be used to synthesize acetylcholine, a neurotransmitter associated with positive influence on memory formation, attention regulation, and learning.
Longevity Starter Bundle
Longevity Starter Bundle includes Pure NMN, Pure TMG, and Pure Resveratrol. Such offerings may offer coordinated support across NAD+ restoration, sirtuin signaling, and methylation balance.
The Pure NMN formula may help support mitochondrial function and repair signaling by improving NAD+ levels in the body. Pure Resveratrol is positioned as the signaling amplifier, which may support sirtuin activity to assist in the repair of damaged DNA cells. Meanwhile, Pure TMG in the bundle could support methyl group availability, which is especially relevant when increasing NAD+ precursor turnover.
Healthy Aging Bundle
The Healthy Aging Bundle is intended to support mitochondrial energy output, oxidative stress control, autophagy support, and DNA maintenance. According to its official site, the bundle includes one bottle each of Pure TMG, Pure NMN, Pure Quercetin, Pure Resveratrol, and Pure Spermidine.
Pure Quercetin and Pure Resveratrol in the bundle may help lower oxidative stress in the cells, with resveratrol tied to sirtuin activation and quercetin tied to antioxidant protection. Pure Spermidine could support autophagy-related cellular renewal, which may help support the elimination of damaged cells and assist in the creation of new ones.Cellular Vitality Bundle
Cellular Vitality Bundle by partiQlar is formulated to stimulate NAD+ pathway activity while supporting NAD+-dependent stress-response signaling. The bundle pairs one bottle each of the Pure NMN and Pure Resveratrol. Such a pairing may help strengthen mitochondrial energy output, metabolic resilience, and long-term cellular maintenance by using two connected mechanisms together rather than relying on either alone.
PartiQlar Advantages
Minimalist Product Portfolio
PartiQlar claims it keeps its product portfolio intentionally small and focused. The brand keeps its lineup on single-ingredient formulations like Pure NMN, Pure NR, Spermidine, and TMG, while avoiding broad blends and wide category expansion. Each product is positioned to serve one clear purpose rather than trying to cover multiple goals in a single formula.
The brand claims this portfolio strategy may support more deliberate stacking and flexible consumption. Single-ingredient formats allow combinations based on personal goals without creating unwanted ingredient overlap, which can happen when multiple products include similar compounds.
PartiQlar further claims it avoids complex excipients, fillers, and binders that are common in multi-ingredient formulas. Ingredient lists are kept short and direct, with the brand stating that it uses high-purity actives, which are often standardized at high percentages and delivered in enteric-coated vegan capsules.
Such a minimalist approach can make it easier to understand exactly what you are taking, adjust dosing more precisely, and avoid fixed-ratio blends that lock product use into preset combinations that may not match your preferences.Data-Based Brand Approach
PartiQlar states that it publishes testing data tied to specific lot numbers through its quality pages. This data is described as covering identity, purity, potency, heavy metals, and microbiological screening. The brand presents the system as a way to verify each production run, meaning quality checks are linked to the exact batch rather than only being tied to the product name.
The brand also claims it goes beyond basic safety disclosures. Alongside MSDS files, PartiQlar provides batch-linked test results that allow matching a purchased product to its exact lab data. The brand’s product pages highlight measurable details like purity percentages, including high-purity NR, exact composition, capsule formats like enteric-coated vegan capsules, and sourcing information.
Such a data-first setup may support independent evaluation and reduce guesswork. Batch-linked testing reports could make it easier to confirm quality at the lot level, while clear product specifications can help with accurate comparisons and more controlled stacking decisions.
PartiQlar Limitation
Narrow Mainstream Awareness
PartiQlar rarely shows up in mainstream rankings, major wellness publications, or broad awareness surveys, which limits how often it enters the general supplement conversation outside niche audiences.
Sales also appear to be centered around the brand’s own website and online channels. PartiQlar has little visibility in national pharmacy chains, grocery stores, or big box retailers, which reduces in-store discovery and lowers the chance of casual exposure during routine shopping.
Due to this narrower reach, mainstream recall remains relatively low. It means that the brand could be discoverable only through targeted searches rather than everyday browsing or retail visibility across Walmart, GNC, or Whole Foods. For you, it could mean extra effort to discover the brand, compare it against more widely available options, and access it through familiar retail channels.
Pros
- Emphasizes manufacturing in US-based FDA-registered, NSF-registered facilities adhering to strict GMP standards.
- The brand’s offerings may target diverse longevity needs, including support for cellular metabolism, antioxidant protection, and metabolic function.
- Claims to focus on GRAS (Generally Recognized as Safe) ingredients backed by research for longevity benefits like NAD+ boosting.
- Offers a 60-day refund policy on purchases.
Cons
- A few users on independent review forums noted inconsistent effects and even no effects after using the brand’s formulations.
- Some users noted delays in refund processing and deliveries on independent review forums.
PartiQlar Alternatives
ProHealth
ProHealth and PartiQlar both operate in the longevity support space and place NAD biology at the center of their positioning. However, the brands have some nuances in terms of their product range, core formulation standards, quality and testing framework, and accessibility.
Founded in 1988 by Rich Carson, ProHealth presents itself as a longevity-oriented brand built around the idea that aging-related decline links to biological changes such as reduced NAD+ activity, weaker mitochondrial energy output, and reduced collagen production. Meanwhile, PartiQlar’s messaging is less focused on founder history and more around precision and simplicity. The brand’s messaging emphasizes single active ingredients, clinically relevant dosing, and the use of minimal excipients throughout its lineup.
Platform breadth and catalog structure also highlight some differences in these brands. ProHealth functions more like a structured longevity store, with categories grouped by biological systems such as NAD+ boosters, AMPK activators, collagen, and antioxidants. The brand offers NMN Pro™ Powder, Trans-Resveratrol Plus Capsules, NMN Pro™ 500, Calcium AKG Longevity, TMG Pro Tablets, Pterostilbene Pro 250, Fisetin Pro Longevity Plus, and Quercetin / Bromelain Complex products. Meanwhile, PartiQlar maintains a narrower and more curated focus, highlighting cellular aging and metabolic longevity pathways with a lineup built around longevity stacks. The brand offers Pure NR, Pure L-Theanine, Pure Alpha GPC, Pure NAD+, Healthy Aging Bundle, and Cellular Vitality Bundle as part of its core lineup.
ProHealth emphasizes guided selection through Longevity Health Pros, described as real advisors who can match you to products after a short set of questions, with ongoing support through text. PartiQlar focuses less on advisor-style navigation and more on formula clarity and stack logic, using minimalist single-ingredient formats to reduce confusion about what is inside each capsule.
ProHealth highlights advisory depth and medical advisor profiles such as Dr. Richard Kaszynski and Dr. Joseph Maroon, using professional oversight as a credibility lever tied to research framing and formulation guidance. Meanwhile, PartiQlar relies on operational rigor and transparency, using lot-matched COAs, third-party testing, and minimal-excipient design.
Renue By Science
When comparing the brands, Renue By Science and PartiQlar both focus on supporting longevity, cellular metabolism, and NAD-related biology. However, the brands differ in their core positioning, range of products, quality standards, and accessibility.
Founded by Bryan Nettles, Renue By Science presents itself as a science-forward longevity brand built around restoring and maintaining NAD+ levels as a foundation for healthy aging. The brand frames NAD+ decline as a major driver of reduced cellular energy, slower recovery, and higher vulnerability to stress-related wear. PartiQlar also positions itself as a longevity-first brand built around precision and transparency, but its structure fits more directly with stack-building behavior.
In terms of catalog breadth, there are some differences between the brands. Renue By Science organizes its catalog around the Boost, Protect, Optimize, and Regenerate NAD+ pathways. This creates a systems-style routine where NAD restoration is only one part of a broader aging strategy that also includes stress defense, metabolic support, and recovery. Some offerings in its catalog are NAD+ Complete Nasal Spray, NMN Pure Powder, Senolytique, Quercetin, Vitamin C, TMG Methylation Essentials, CaAKG, Restore PM Gel, Spermidine, and Melatonin.
Meanwhile, PartiQlar uses a more streamlined longevity stack model, emphasizing the Healthy Aging Bundle, Longevity Starter Bundle, Anti-Inflammatory Bundle, and Blood Sugar Balance Bundle. Singular options are listed as Pure NR, Pure NAD+, Pure Alpha GPC, Pure Berberine HCL, Pure L-Theanine, and Pure Spermidine.
Renue By Science leans into delivery engineering, especially liposomal delivery. The brand describes liposomes as wrapping actives such as NMN or NR in phospholipids to protect them during digestion and reduce loss through first-pass metabolism. This delivery focus is reinforced by the format variety, like liposomal capsules, gels, fast-dissolve tablets, nasal sprays, and enteric-coated options. Meanwhile, PartiQlar is less delivery-focused and more formulation-minimalist, keeping attention on capsule simplicity, minimal excipients, and clean-label rules.
Sourcing transparency adds another meaningful difference in the shared content. Renue By Science explicitly addresses NMN sourcing and states its raw NMN is sourced from China, noting it currently sources exclusively from Effepharm while maintaining relationships with other suppliers for continuity. PartiQlar does not include the same type of supplier-specific sourcing disclosure in the provided content, and instead keeps reassurance centered on U.S.-based manufacturing framing, third-party testing, and lot-verified documentation.
How Did We Evaluate?
Brand Credibility
In evaluating PartiQlar’s reputation, we analyzed the brand’s operational consistency, core positioning, and presence across independent review forums. On Trustpilot, the
Many users described improvements in energy levels, focus, sleep, and vitality after using the brand’s offerings. However, a few users complained about delayed shipping and poor customer service handling, including reports of orders stuck in transit for weeks, lack of shipping notifications, long time on hold, and support interactions described as unhelpful or disrespectful. There are also subscription-related complaints where some users mentioned they were not aware they signed up for a subscription and could not cancel successfully.
Meanwhile, TenereTeam provided the brand with a 4.2 out of 5 score that was explicitly tied to a very limited number of reviews on the platform. The low review volume on TenereTeam could limit the strength of cross-platform validation.
Based on our evaluation, it appears that the brand benefits from strong product satisfaction narratives and trust-building language around testing and purity. However, recurring concerns around shipping traceability, support accessibility, cancellation clarity, and refund processing timelines indicate areas of improvement for the brand.Real User Feedback
To evaluate PartiQlar, we reviewed the verified user reviews for the brand’s two core products across Amazon to assess how they perform in real-world use.
Pure Alpha GPC maintains a 4.3 out of 5 score from 35+ reviews. Many users experienced noticeable improvements in focus, stamina, and libido after using the product. Packaging and manufacturing cues were also repeatedly highlighted, including made in double-sealing, best-by dating, and easy-to-swallow capsules. However, a few users expressed concerns about fillers and non-active ingredients, specifically calling out silica and microcrystalline cellulose.
Based on the available feedback, many users appreciated the brand’s offerings for their effects on energy levels, focus, and metabolism. However, critical feedback is also reflected, particularly around inconsistency in benefits, potency issues, and premium pricing of products.
Frequently Asked Questions
No. The brand does not provide personalized product recommendations through quizzes, algorithms, or guided tools. Its website focuses on single-ingredient formulations and encourages you to build your own stacks manually.
Yes. The brand states that potential product interactions are possible. For example, Pure Spermidine may interact with anticoagulants and blood pressure medications, while Pure Berberine HCL may interact with diabetes medications. The brand advises consulting a healthcare professional before use when taking medications.
No. The brand states most products avoid gluten, GMOs, and unnecessary additives, and it uses vegetarian capsules. However, it does not provide a universal allergen-free guarantee across its full lineup (e.g., covering soy, nuts, dairy, or cross-contact risk). Allergen status should be verified per product and via COAs if available.
Conclusion
PartiQlar claims to provide NAD+ pathway support. Its catalog is structured around clean, primarily single-ingredient formulations, with manufacturing described as GMP-certified and quality framing tied to third-party testing.
Before opting for the brand’s offerings, it is essential to consider some limitations and considerations. Due to the brand’s online-focused distribution model, the orders are vulnerable to shipping delays and mismanagement.
Outcome variability and tolerance monitoring remain central because the effects of NAD+ offerings from the brand are not uniform. Highlighted benefits like improved energy, mitochondrial support, and sirtuin-related pathway influence depend on baseline health, age, diet, and sleep. Stacking longevity formulations may warrant added caution due to their potential influence on metabolic signaling pathways, including mTOR- and autophagy-linked mechanisms.
- About the Author
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Alisha Matthew has been a practicing nutritionist since 2016. She holds a master’s degree in nutrition from the University of IOWA. She is a staunch believer in improving the human health index by educating people about nutrition and the importance of nutrition in leading a healthy and happy life. Her long-term goal is to keep educating people on general health and keep herself updated with the latest trends in the field of health.