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15 Biotin Side Effects


Biotin is a vitamin also known as vitamin B-7 that forms fatty acids and glucose. It also helps in the metabolism of carbohydrates and amino acids.

This vitamin is responsible for breaking down fats in your body. In sports, creating the energy your body needs is vital.

Biotin is generally found in a lot of food items. These food items include milk, carrots, salmon, and nuts. All these food substances are loaded with the benefits of biotin.

You may also consume biotin in supplement form. However, it should only be done after consulting a doctor.

In this article, we will discuss all the side effects that it might have.

Side Effects Of Biotin

Usage of biotin in excess amounts can be alarming for a person.

Even though the excess biotin in the body is flushed out through urination, still, there are remaining chances of bad impacts of it on your body.

Majorly, biotin comes as harmful if consumed through supplements. That is why it is recommended to consume biotin supplements after consultation with the doctor.

When it comes to major side effects of biotin then few can be counted as follows.

  1. Interaction With Medications

    Biotin consumption should be regulated if taking medication for some medical conditions.

    Vitamins and biotin can have negative effects if consumed with certain medications. One of those[1] medications is anticonvulsant medication.

    Currently, there have no adverse effects of biotin if consumed according to a doctor’s prescription.

    This study[2] concluded that smoking can increase the catabolism of biotin in women, hence, resulting in a deficiency of it.

  2. Acne

    Excessive biotin consumption can cause acne on your face. Your body absorbs biotin the same way other vitamins and minerals are absorbed.

    Acne in your gastrovascular is absorbed to reduce your body. The consumption of biotin in excess amounts becomes an obstacle to the absorption of acne.

    It ultimately increases acne on your skin. Such instances occur because of the reduction of vitamins that fight acne and remove it from your body.

  3. Skin Rashes

    Skin rashes are quite irritating and are a friend of biotin if you consume it in excess quantities or may get a deficiency of this vitamin.

    A study[3] confirmed that from children to adults, everyone could experience red and scaly skin rashes on their skin due to its deficiency.

    Rashes appear because of inflammation of blood vessels. Biotin causes such problems because it is considered a foreign element in your system.

  4. Stomach Problems

    Excessive biotin in your body can cause problems with your stomach in the gut which can be alarming at certain stages.

    Biotin upsets your digestion. Therefore, it causes[4] many stomach problems like cramps, nausea, and diarrhea.

    This is why it is best to go for an organic option rather than a biotin supplement.

  5. Incorrect Lab Results

    Excessive amounts of biotin in your system can give incorrect lab results. Faulty[5] lab results can be problematic in diagnosis.

    Situations like these may cause the wrong diagnosis of diseases or illnesses. To avoid such situations, it is advised to stop consuming biotin a few days before the lab testing.

  6. Weight Gain

    Since biotin is related to obesity in diabetes, it may cause weight gain. Biotin, directly, does not increase weight in your body.

    Surprisingly, it influences your cravings and appetite which, in turn, increases your weight. Since biotin digests food easily, it leaves your stomach empty for a long time.

    This impact may increase[6] your hunger and hence your weight.

  7. Kidney Problems

    Since biotin is water soluble, it comes along in the kidneys. If not filtered, the vitamin remaining in the kidneys can cause many kidney problems.

    The non-required vitamins are the only ones that cause such a problem[7]. Such a delay in vitamin clearance can cause a lot of difficulties too.

  8. Biotin Deficiency

    In contrast to excessive biotin, a lack of biotin causes biotin deficiency. Excessive consumption of raw eggs can be the cause of biotin deficiency.

    As a result[8] of such deficiency, you can experience conjunctivitis, hair thinning, and skin problems.

    This proves that biotin is quite important for our body. It is always recommended to consume a stipulated amount of dosage when it comes to biotin.

    There aren’t many bad impacts of this vitamin. Even so, an excessive amount of biotin in a body can be diagnosed with thyroid diseases.

    This is why doctors prescribe you to consume biotin in a certain amount.

  9. Stomach Ache

    Biotin is normally known for soothing your stomach and improving digestion. But in the case of overconsumption of biotin supplements, you might observe the opposite.

    Too much biotin may lead to stomach aches and uneasiness. Moreover, you might get nauseous. This stomach ache may worsen diarrhea.

    In case you observe such symptoms, stop or gradually decrease your supplements. Consult the doctor as soon as possible.

  10. Decreased Blood Sugar Levels

    Normally, biotin helps lower blood sugar levels. But excess can lead to a drastic drop in blood sugar levels.

    This is observed more in people taking insulin. This may worsen to an extent of a condition called hypoglycemia.

    Some opposite results can also be observed in diabetic patients. There can be some cases of high blood sugar levels. So use it with caution[9].

  11. Liver Problems

    Biotin affects insulin levels. It enhances insulin secretion which differs from normal body functioning. This may affect the working of the liver.

  12. Vitamin Deficiency

    Biotin might lower both vitamin C and B6 levels. A decrease in vitamin C affects your immunity.

    Similarly, a drop in vitamin B6 levels leads to neurological problems as B vitamins like B1, B6, and B12 combine to play a significant role in the nervous system, as per this study[10].

  13. Hair Loss

    Biotin might work wonders for your hair if taken correctly. Excess of the same might make you shed some hair.

    A research paper[11] stated that if you do not use proper hair care and appropriate biotin supplements, it may cause more harm than benefit.

  14. Allergic Reaction

    Allergies are hard to detect unless you are exposed[12] to the thing you are allergic to. Biotin allergy might cause rashes and swelling of the face and neck.

    Additionally, you might feel sick and experience hot flashes. Stop the use of biotin in case of such symptoms.

  15. Trouble In Sleeping

    Biotin might relieve sleeping problems and anxiety. But overdose of biotin increases the risk[12] of trouble falling asleep. It might even cause insomnia in the long run.


Biotin is a vitamin that is present in our daily food items. You can easily find it in legumes, egg yolks, milk, soybean, and many other food items.

Consumption of such food items regularly in usual amounts fulfills your biotin requirements.

It is suggested to consume not more than 30 micrograms of biotin regularly. The measurement applies to people above 13 years of age.

Biotin has many health benefits if consumed in the right amount. To avoid any adverse reaction to biotin consumption, you must confer with your doctor regarding the dosage of this vitamin.


Working4Health prefers using primary and verified references. We have strict sourcing guidelines and our primary references include peer-reviewed research, academic, and medical institution studies.

  1. H M Said, R Redha, W Nylander Biotin transport in the human intestine: inhibition by anticonvulsant drugs Am J Clin Nutr. 1989 Jan;49(1):127-31. doi: 10.1093/ajcn/49.1.127. Available from: https://pubmed.ncbi.nlm.nih.gov/2911998/
  2. Wendy M Sealey, April M Teague, Shawna L Stratton, et al. Smoking accelerates biotin catabolism in women Am J Clin Nutr. 2004 Oct;80(4):932-5. doi: 10.1093/ajcn/80.4.932. Available from: https://pubmed.ncbi.nlm.nih.gov/15447901/
  3. D M Mock Skin manifestations of biotin deficiency Semin Dermatol. 1991 Dec;10(4):296-302. Available from: https://pubmed.ncbi.nlm.nih.gov/1764357/
  4. H M Said, A Ortiz, E McCloud, et al. Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid Am J Physiol. 1998 Nov;275(5):C1365-71. doi: 10.1152/ajpcell.1998.275.5.C1365. Available from: https://pubmed.ncbi.nlm.nih.gov/9814986/
  5. Danni Li, Angela Radulescu, Rupendra T Shrestha, et al. Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults JAMA. 2017 Sep 26;318(12):1150-1160. doi: 10.1001/jama.2017.13705. Available from: https://pubmed.ncbi.nlm.nih.gov/28973622/
  6. Shi-Sheng Zhou and Yiming Zhou Excess vitamin intake: An unrecognized risk factor for obesity World J Diabetes. 2014 Feb 15; 5(1): 1–13.Published online 2014 Feb 15. doi: 10.4239/wjd.v5.i1.1
  7. Miora Koloina Ranaivosoa, Sébastien Ganel, Arnaud Agin, et al. [Chronic kidney failure and biotin: A combination inducing unusual results in thyroid and parathyroid investigations, report of 2 cases] Nephrol Ther. 2017 Dec;13(7):553-558. doi: 10.1016/j.nephro.2017.02.016. Epub 2017 Nov 10. Available from: https://pubmed.ncbi.nlm.nih.gov/29133077/
  8. Fatima Saleem; Michael P. Soos. Biotin Deficiency Last Update: March 2, 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547751/
  9. Xuesong Xiang, Yan Liu, Xuesong Zhang, et al. [Effects of biotin on blood glucose regulation in type 2 diabetes rat model] Wei Sheng Yan Jiu. 2015 Mar;44(2):185-9, 195. Available from: https://pubmed.ncbi.nlm.nih.gov/25997216/
  10. Carlos Alberto Calderón‐Ospina and Mauricio Orlando Nava‐Mesa B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin CNS Neurosci Ther. 2020 Jan; 26(1): 5–13.Published online 2019 Sep 6. doi: 10.1111/cns.13207
  11. Barry Wolf Biotinidase Deficiency Last Update: June 9, 2016. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1322/
  12. Karlyle G. Bistas; Prasanna Tadi. Biotin Last Update: July 4, 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554493/

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