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8 Cardarine Side Effects


Cardarine is a peroxisome proliferator activator receptor (PPAR) delta agonist highly effective in the prospective treatment of dyslipidemia.

Cardiovascular disease, obesity, and lipid disorders could all be controlled with Cardarine usage as a therapeutic.

In several tissues, including adipose tissue and skeletal muscle, the Cardarine medication controls the oxidization of fatty acids.

The oxidative capacity of muscles can be increased when a lot of PPAR-delta copies are made utilizing a transgenic mouse model.

Cardarine might also significantly impact metabolic adjustments among people with high saturated fat diets.

According to the believers of Cardarine, supplements containing Cardarine aid in increasing muscle cells’ metabolism and may also aid in reducing fat storage by promoting the breakdown of fat, also known as lipolysis.

They claim that Cardarine is thought to be a highly effective non-stimulant that is excellent in boosting endurance and human muscular growth.

It promotes the PPAR-delta pathway, which helps to activate many genes related to fat burning and is said to speed up the fat-burning process.

It may also change how your body responds to food with a higher glycemic index.

One might note that the FDA disapproves of Cardarine for consumption. As a result, we will never recommend the same to anyone.

For SARMs like benefits, one could consider alternatives to SARMs. By doing so, there are high chances that one may be able to avoid other SARMs side effects altogether.

However, there are many side effects of Cardarine that might be hazardous to one’s health. The following are a few noteworthy ones.

Side Effects Of Cardarine

The following are some of the side effects associated with cardarine-

  1. Might Lead To Liver Damage

    Cardarine is consumed regularly in the sports industry and its consumption is growing at a rapid pace. Therefore, liver harm instances are very common among sports professionals.

    Like many drugs, cardarine might harm the liver of people who are its long-term users. Medical symptoms, such as increased liver enzymes and jaundice could result from liver damage.

    According to this observation[1], cardarine’s mechanism of action is similar to steroids and sometimes could result in cholestatic liver damage among its users.

    However, instances[2] of liver problems brought on by cardarine usage are very uncommon and usually happen when the supplement is taken more than the recommended dosages.

  2. Change In Blood Sugar And Body Fat

    Cardarine use leads to a rise in blood sugar. People who have[3] type 2 diabetes are going to be seriously affected by it.

    So, while taking cardarine, patients need to make sure their blood sugar is regularly measured and tracked. Blood sugar will return to normal after the medication is stopped.

    Cardarine significantly boosts[4] cortisol levels which leads[5] to considerable weight gain. Adrenal atrophy and adrenal insufficiency can result from adrenal suppression.

    When cortisol level increases in the body, it can cause the adrenal glands, which create cortisol, to shut down.

    Cushing syndrome, a rare[6] illness that redistributes fat throughout the entire body, can be brought on by an excess of cortisol levels in the body.

    The distribution of fatty tissue around the waist, between the shoulder blades, and on the face are indicators of Cushing syndrome.

  3. May Disturb The Production Of Testosterone In Men

    Cardarine makes your body fill up with androgen, negating the requirement for your body in producing its natural androgens.

    As a result, when the levels of androgen rise in your body, it stops producing[7] its testosterone.

    The body ceases to produce testosterone as the body’s requirement for natural androgen gets reduced when it is overflowed with cardarine that binds[8] to the androgen receptor.

    Additionally, when androgen levels are at their peak, your body won’t use any extra energy on manufacturing testosterone.

    Thus, by doing this, your body limits its natural testosterone production and will begin to show[9] signs of low testosterone.

  4. May Cause Cardiovascular Conditions

    Cardarine users who take medium doses to high doses run the risk of developing a buildup of excess cholesterol in the arteries, also known[10] as early atherosclerosis.

    This can eventually cause the clotting of blood or restrict the blood flow. Low-cholesterol diet and regular exercise are the ways to deal with atherosclerosis.

    Inconsistencies in phosphate, calcium, and potassium levels might result from prolonged periods of consuming cardarine.

    Weight gain, irregular heartbeats, high blood pressure, and edema (swelling) are common phenomena that might result from this.

    Diuretics (or water tablets) and a low-sodium diet may be suggested[11] by your doctor to assist you in preventing fluid retention and in the management of blood pressure.

  5. Could Interfere With The Menstrual Cycle

    Cardarine usage among women may cause[12] their menstrual cycles to become irregular. Cardarine increases the androgen hormone in a female’s body.

    Women could experience hormonal abnormalities, such as the very common polycystic ovarian syndrome (PCOS) as a result of an overabundance of androgen hormones in their bodies.

    Women who suffer from polycystic ovarian syndrome have irregular menstrual cycles that may run late or early. Irregular menstrual cycles are often painful, unpleasant, and uncomfortable in women.

    Also, for women, hormonal diseases like PCOS are usually accompanied by several additional underlying medical conditions.

  6. Might Cause Mental Health Issues

    Cardarine may boost mild euphoria, hypomania, anxiety, and emotions of well-being in the early stages of treatment (usually within a few days). But with prolonged therapy, people might experience depression.

    When using cardarine for quite a long time, doses of 30 mg or more per day could cause[13] psychosis, medically termed corticosteroid-induced psychosis.

    Patients using 50 mg or less might experience 1.2 percent of psychosis cases, whereas those taking 70-80 mg daily might experience 19 percent of instances.

    Patients that have a history of mental health problems and who are identified as females are often more vulnerable to cardarine.

    However, after the medication is stopped, most people should no longer experience these symptoms.

    Although mental health symptoms could appear at any moment, they usually might begin to show 3 to 4 days after starting on cardarine medication.

    Even after stopping the medication, some people might continue to experience depression.

    Cardarine may also result in behavioral symptoms, such as euphoria, manic behavior, melancholy, mood swings, sleeplessness, and hostility in children who have acute lymphoblastic leukemia.

  7. May Increase Infection Risk

    Cardarine’s ability to inhibit the body’s immunological response increases the chance of contracting infections.

    Tell your doctor right away if you begin to show any infection-related symptoms while taking cardarine, such as a sore throat, cough, runny nose, or fever.

    By avoiding contact with people who are sick with a cold or the flu and often washing your hands, you can reduce the risk of contracting an infection.

    Doctors will typically advise people on cardarine medication to have a flu shot (non-live) annually and a few other vaccinations as well.

  8. Might Cause Hypercalcemia

    The intestines can absorb more calcium and release it into your body when cardarine levels are higher. The result is hypercalcemia.

    The majority of cardarine-related issues originate[14] from hypercalcemia.

    When the density of calcium increases in the blood, this ailment manifests. Hypercalcemia, or excessive calcium density, might result in symptoms like:

    • High blood pressure
    • Unexplained exhaustion
    • Diarrhea
    • Loss of appetite
    • A metallic taste in the mouth
    • Reduced reflexes
    • An irregular heartbeat
    • Increased thirst leads to more frequent urination
    • Muscle weakness

    Additionally, blood vessel constriction in the kidneys brought on by hypercalcemia could result in the diminished function of the kidneys.

    Numerous patients have noted mild to moderate renal damage in those who are prolonged receivers of cardarine treatments.


The drug cardarine is known to improve athletic performance and increase fat reduction. This is primarily based on hearsay of numerous cardarine users throughout the medical community.

The substance cardarine appears to have most of its potential as a performance enhancer when you pay attention and dive deep into the experiences that bodybuilders discuss online.

Unfortunately, it also comes with a lot of disadvantages which might hurt your overall health. Sometimes people utilize it in significantly large numbers at their peril.

Cardarine is overall a dangerous choice in light of the dearth of the drug’s dubious sources, the danger of its adverse effects, and the extensive complaints among its users.


Working4Health prefers using primary and verified references. We have strict sourcing guidelines and our primary references include peer-reviewed research, academic, and medical institution studies.

  1. Zachary J. Solomon, Jorge Rivera Mirabal, Daniel J. Mazur, et al. Selective Androgen Receptor Modulators (SARMs) – Current Knowledge and Clinical Applications. Sex Med Rev. 2019 Jan; 7(1): 84–94. Published online 2018 Nov 30. doi: 10.1016/j.sxmr.2018.09.006
  2. Liver Disease. Available from https://www.niddk.nih.gov/health-information/liver-disease
  3. Afiat Berbudi, Nofri Rahmadika, Adi Imam Tjahjadi, et al. Type 2 Diabetes and its Impact on the Immune System. Curr Diabetes Rev. 2020 May; 16(5): 442–449. Published online 2020 May. doi: 10.2174/1573399815666191024085838
  4. Lauren Thau; Jayashree Gandhi; Sandeep Sharma. Physiology, Cortisol. Last Update: September 6, 2021. Available from https://www.ncbi.nlm.nih.gov/books/NBK538239/
  5. SB Abraham, D Rubino, N Sinaii, S Ramsey, et al. Cortisol, obesity and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature. Obesity (Silver Spring). 2013 Jan; 21(1): E105–E117.doi: 10.1002/oby.20083
  6. Cushing’s Syndrome. Available from https://www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome
  7. George N. Nassar; Stephen W. Leslie. Physiology, Testosterone. Last Update: January 4, 2022. Available from https://www.ncbi.nlm.nih.gov/books/NBK526128/
  8. Rachel A Davey and Mathis Grossmann. Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Clin Biochem Rev. 2016 Feb; 37(1): 3–15.
  9. Low testosterone. Available from https://www.healthdirect.gov.au/low-testosterone
  10. Atherosclerosis. Available from https://medlineplus.gov/atherosclerosis.html
  11. Tips for taking diuretic medications. Available from https://www.health.harvard.edu/heart-health/tips-for-taking-diuretic-medications
  12. Sari M Van Anders, Neil V Watson. Menstrual cycle irregularities are associated with testosterone levels in healthy premenopausal women. Am J Hum Biol. 2006 Nov-Dec;18(6):841-4. doi: 10.1002/ajhb.20555. Available from https://pubmed.ncbi.nlm.nih.gov/17039468/
  13. Michael Janes, Shaw Kuster, Tove M. Goldson, et al. Steroid-induced psychosis. Proc (Bayl Univ Med Cent). 2019 Oct; 32(4): 614–615.Published online 2019 Jul 22. doi: 10.1080/08998280.2019.1629223
  14. Nazia M. Sadiq; Srividya Naganathan; Madhu Badireddy. Hypercalcemia. Last Update: November 26, 2021. Available from https://www.ncbi.nlm.nih.gov/books/NBK430714/

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